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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Clin Exp Metastasis. 2015 Dec 14;33(3):239–248. doi: 10.1007/s10585-015-9773-7

Fig. 2.

Fig. 2

Twist expression in human primary PCa and CRPC metastases. a Cytoplasmic and nuclear staining profile of Twist in benign/normal prostate (NP), Gleason (Gl) pattern 3 and 4 prostate carcinoma. Both nuclear and cytoplasmic Twist expression is higher with increasing Gleason grades. b Nuclear Twist is expressed in a subset of cells displaying EMT-like behavior in CRPC bone and visceral metastases. Cytoplasmic and nuclear Twist expression is higher bone metastases (p < 0.001). Staining intensities (intense, moderate, weak, or no staining) are described in the inset in Fig. 1. Patients—represents the number of patients represented, sites—represents the number of metastases. Examples of nuclear Twist and Pan-cytokeratin staining in a CRPC bone metastasis are shown to the lower right. White arrows highlight epithelial cells with elongated nuclei and the black arrows highlight cells with round nuclei. Bar = 40 microns