Table 1.
Somatic mtDNA mutations in metastases from a CRPC patient
| Tissue | Somatic mtDNA mutation (position type) |
|||
|---|---|---|---|---|
| 4048 G>A | 12390 ins(C) | 4430 ins(G) | 4480 T>G | |
| Kidney (normal) | – | – | – | – |
| Muscle (normal) | – | – | – | – |
| Prostate (primary tumor) | + | – | – | – |
| Adrenal | + | – | – | – |
| Lung | + | – | – | – |
| Retroperitoneal lymph | + | – | – | – |
| Sternum | + | – | – | – |
| Vertebrae, T10 | + | – | – | – |
| Liver | + | + | – | – |
| Spleen | + | + | – | – |
| Vertebrae, L1 | + | + | – | – |
| Vertebrae, L2 | + | + | – | – |
| Vertebrae, L4 | + | + | – | – |
| Vertebrae, L5 | + | + | – | – |
| Vertebrae, T8 | + | + | – | – |
| Vertebrae, T9 | + | + | – | – |
| Pelvic lymph node | + | + | + | – |
| Tracheal lymph node | + | + | – | + |
The mitochondrial genome was sequenced from two normal tissues, the primary tumor, and fifteen separate metastases in a castration-resistant prostate cancer patient. Somatic mtDNA mutations were discovered in four genes among the metastases: ND1 (4048 G>A), ND5 (12390 insert C), tRNA M (4430 insert G), ND2 (4480 T>G). mtDNA sites are labeled as wild-type (“–”) or mutant (“+”) for each tissue