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. 2016 Jan 21;23(3):272–282. doi: 10.1038/gt.2015.112

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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AAV2-2 transduces large projection neurons, mainly CSMN in the motor cortex. Co-immunolabeling with eGFP and cell-type-specific markers reveals transduction efficiencies of neurons (a) and CSMN (b) in the motor cortex. (a) A representative image of AAV2-2 eGFP+-transduced cells expressing NeuN. Boxed areas in representative images are enlarged to the right. (b) A representative image of AAV2-2 eGFP+-transduced cells expressing Ctip2. (c–f) Bar graphs represent mean percentage ±s.e.m. of neurons (eGFP+ cells, expressing neuronal marker NeuN) (c), CSMN (eGFP+ cells, expressing Ctip2) (d), astrocytes (eGFP+ cells, expressing GFAP) (e) and microglia (eGFP+ cells, expressing Iba1) (f). One-way ANOVA and Tukey's multiple comparison test, AAV2-2 versus all other serotypes. *P<0.05, **P<0.01, ***P<0.001. Scale bars 10 μm (b), 50 μm (d, e).