Figure 2.

Clonality assessment in two representative cases of essential thrombocythemia. (a) Allele frequencies of mutations in patient E1. (b) Clusters of variants identify the founding clone in patient E1. (c) Allele frequencies of mutations in patient E3. (d) Clusters of variants identify the founding clone and subclones in patient E3. In (b) and (d), the allele frequency is plotted versus the total number of sequencing reads covering the corresponding mutated nucleotide.