TABLE 1.
Mouse characterization of metabolic parameters at end of study
Data are the means ± S.E. n = 6 per group. Data were collected at end of study (i.e. day 50).
| Parameters | Lean | Obese + vehicle | Obese + CDN1163 |
|---|---|---|---|
| Glucose (mg/dl) | 85.2 ± 2.60 | 365.4 ± 25.16a | 129.6 ± 6.38b |
| Insulin (ng/ml) | 1.08 ± 0.03 | 7.70 ± 0.89c | 6.30 ± 0.28d |
| Food intake (g/day) | 4.78 ± 0.41 | 5.45 ± 0.26e | 5.18 ± 0.18f |
| Body weight (g) | 27.2 ± 0.73 | 57.8 ± 1.32a | 55.3 ± 0.60 |
| Liver weight (g) | 1.06 ± 0.18 | 3.13 ± 0.19a | 2.69 ± 0.26f |
| Liver/body (%) | 2.96 ± 0.12 | 5.61 ± 0.33e | 4.57 ± 0.26 |
| Epididymal fat (g) | 0.52 ± 0.07 | 3.89 ± 0.10a | 3.26 ± 0.07f |
| Plasma TG (mg/dl) | 96.7 ± 7.95 | 371.7 ± 37.68e | 188.3 ± 20.28f |
| Liver TG (mg/g) | 31.5 ± 2.75 | 208.9 ± 16.12e | 147.3 ± 26.47f |
| Plasma free fatty acids (mmol/liter) | 1.65 ± 0.09 | 1.90 ± 0.17 | 1.76 ± 0.08 |
| Plasma cholesterol (mg/dl) | 71.65 ± 8.67 | 180.73 ± 11.64e | 118.20 ± 0.08f |
| Plasma MDA (μm) | 1.80 ± 0.37 | 6.83 ± 2.20 | 3.50 ± 3.97f |
| Liver MDA (μmol/g) | 6.88 ± 2.82 | 13.92 ± 1.11e | 8.89 ± 1.39 |
a p < 0.001 lean vs. obese.
b p < 0.001 obese vs. obese + CDN1163.
c p < 0.01 lean vs. obese.
d p < 0.01, obese vs. obese + CDN1163.
e p < 0.05, lean vs. obese.
f p < 0.05, obese vs. obese + CDN1163.