FIGURE 1.

The structure of NATs is incompatible with lysine acetylation. A, superposition of the Gcn5 KAT-histone H3 peptide complex (dark and light blue, respectively) with the Naa10 N-terminal peptide complex (yellow and wheat, respectively). The proteins are shown as cartoon and the peptide ligands are shown as sticks. Naa10 is shown with its β6-β7 loop in orange. B, superposition of NAT/N-terminal peptide complexes with Naa10 (yellow), Naa40p (salmon) Naa50p (green), and the NAT from Sulfolobus solfataricus (ssNAT, purple).