FIGURE 9.
AllosMod-FoXS modeling of the open and closed conformations of dimeric apoA-IΔ185–243. a and b, the best fit open and closed conformations are superimposed onto the ab initio dimeric apoA-IΔ185–243 molecular envelope in a and b, respectively. c, comparison of the experimental dimeric apoA-IΔ185–243 x-ray scattering profile (black line) to the best fit open (green line), closed (purple line), and two-state (orange line) theoretical profiles with the chi distribution in parenthesis. d, the residual scatter plot normalized to the experimental scatter profile (black dotted line). e, cross-linking data from Tables 1 and 2 superimposed on a molecular contact blot generated from the best fit of the combined open (dark) and closed (light) models.