Table 2. WHO-recommended preventive regimens for latent tuberculosis infection41 .
| Regimen* | Dosage | HepatotoxicityOR (95% CI) | Treatment efficacy | |
| 6INH | Children: 10 mg/kg/d Adults: 5 mg/kg/d Maximum dose: 300 mg | Compared to placebo: 0.99 (0.42–2.32) | Equivalent to 9INH and 3RPT + INH regimens | |
| 9INH | Children: 10 mg/kg/d Adults: 5 mg/kg/d Maximum dose: 300 mg | – | Equivalent to 6INH and 3RPT + INH regimens | |
| 3-4RIF | Children: 10 mg/kg/d Adults: 10 mg/kg/d Maximum dose: 600 mg | Compared to 6INH: 0.03 (0.00–0.48) | Maybe equivalent to 6INH regimen | |
| 3-4RIF + INH | Rifampicin: Children: 10 mg/kg/d Adults: 10 mg/kg/d Maximum dose: 600 mg | Isoniazid:Children: 10 mg/kg/d Adults: 5 mg/kg/d Maximum dose: 300 mg | Compared to 6INH: 0.89 (0.52–1.55) | Maybe equivalent to 6INH regimen |
| 3RPT + INH | Rifapentine: 10.0–14.0 kg: 300 mg 14.1–25.0 kg: 450 mg 25.1–32.0 kg: 600 mg 32.1–49.9 kg: 750 mg Maximum dose: 900 mg | Isoniazid:Children: 15 mg/kg/d Adults: 15 mg/kg/d Maximum dose: 900 mg | Compared to 6INH: 1.0 (0.50–1.99)Compared to 6INH: 0.16 (0.10–0.27) | Equivalent to 6INH and 9INH regimens |
*
Regimen: 6INH: daily isoniazid for 6 months; 9INH: daily isoniazid for 9 months; 3-4RIF: daily rifampicin for 3–4 months; 3–4RIF + INH: daily rifampicin plus isoniazid for 3–4 months; 3RPT + INH: weekly rifapentine plus isoniazid for 3 months.