Table 1. Genes with significant alterations in modern Beijing strains.

Gene name	Genetic changes	Alteration	Cellular localization	Description
Rv1730c	19 bp deletion from codon 438 to 444	517–>418 amino acids	Cell wall and cell processes	Essential, possible penicillin-binding protein, involved in cell wall biosynthesis and may also act as a sensor of external penicillin
Rv2147c	1 bp deletion in start codon	241–>218 amino acids	Cell membrane	Essential, a core mycobacterial gene, conserved in mycobacterial strains
Rv2148c	1 bp deletion in codon 258	Frameshift of 5 amino acids	Cell membrane	Nonessential, conserved protein, function unknown
Rv2180c	A premature stop codon mutation	295–>249 amino acids	Cell wall and cell processes	Nonessential, probable conserved integral membrane protein, function unknown