Table 2. Modern Beijing-specific mutations that are enriched in the gene category of regulatory network and other mutations with potential functional effects.

Categories	Gene	Codon change	Gene description
Regulatory network	pknA	Q370P	Transmembrane serine/threonine protein kinase A
		Q369R	Transmembrane serine/threonine protein kinase A
	Rv0452	H125D	Possible transcriptional regulatory protein
	Rv0890c	E234G	Probable LuxR family transcriptional regulatory protein
	Rv2488c	T265I	Transcriptional regulator, LuxR family
	Rv3173c	Promoter mutation	TetR/AcrR family transcriptional regulator
Other categories	secA2	V410M	Possible preprotein translocase ATPase SecA2
	sseA	E276K	Probable short-chain dehydrogenase/reductase
	glcB	G104S	Probable malate synthase G GlcB