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Schematic presentation of the role of BH4 in the formation of citrulline, NO and O2∙- by NOS. a Situation in which there is sufficient supply of BH4 for NOS. b Situation in which there is insufficient supply of BH4. Some cellular sources of NOS will generate O2∙- instead of NO and citrulline. Generation of O2∙- and NO together will lead to the formation of peroxynitrite, which may cause oxidative damage.
