Table 1.
Physiological parameters
| Baseline | After haemorrhage | Resuscitated | ||
|---|---|---|---|---|
| MAP (mmHg) | ||||
| FFP | 82 ± 18 | 53 ± 9 | 68 ± 11 | *# |
| ALB | 74 ± 20 | 54 ± 12 | 70 ± 10 | *# |
| RA 4.5 | 100 ± 9 | 50 ± 6 | 57 ± 7 | |
| SHAM | 84 ± 7 | 100 ± 20 | 90 ± 18 | |
| ScvO2 (%) | ||||
| FFP | 82 ± 5 | 40 ± 9 | 75 ± 7 | * |
| ALB | 78 ± 11 | 44 ± 14 | 74 ± 9 | * |
| RA 4.5 | 85 ± 3 | 46 ± 9 | 65 ± 11 | * |
| SHAM | 82 ± 7 | 75 ± 5 | 76 ± 8 | |
| Lactate (mmol/L) | ||||
| FFP | 2.2 ± 0.5 | 6.0 ± 1.9 | 1.8 ± 0.7 | * |
| ALB | 2.2 ± 0.5 | 6.5 ± 3.3 | 1.2 ± 0.5 | *# |
| RA 4.5 | 2.0 ± 0.7 | 5.4 ± 1.1 | 2.4 ± 1.4 | * |
| SHAM | 1.8 ± 0.3 | 2.1 ± 1.1 | 1.8 ± 0.2 | |
| Base excess (mmol/L) | ||||
| FFP | 5.1 ± 1.2 | −3.9 ± 3.8 | 5.9 ± 1.0 | *† |
| ALB | 5.1 ± 1.4 | −4.4 ± 6.4 | 0.9 ± 1.8 | |
| RA 4.5 | 5.4 ± 1.4 | −2.8 ± 2.6 | 0.3 ± 2.2 | |
| SHAM | 6.0 ± 1. | 3.2 ± 1.6 | 2.2 ± 2.2 | |
| Haematocrit (%) | ||||
| FFP | 42 ± 1 | 33 ± 3 | 19 ± 2 | * |
| ALB | 42 ± 3 | 33 ± 5 | 18 ± 3 | * |
| RA 4.5 | 42 ± 1 | 31 ± 5 | 20 ± 3 | * |
| SHAM | 42 ± 1 | 39 ± 4 | 40 ± 6 | |
Data presented as mean ± SD. The change in values after resuscitation compared to after haemorrhage within groups was evaluated with paired t test corrected for multiple analyses with the Bonferroni correction (*P < 0.05). Differences in between groups after resuscitation was analysed with one-way repeated measurement ANOVA followed by post hoc testing using the Newman-Keuls correction
MAP mean arterial pressure, ScvO 2 central venous oxygen saturation, FFP fresh frozen plasma, ALB albumin, RA Ringer’s acetate
#Significant difference compared to the RA group
†Significant difference compared to ALB and RA groups, P < 0.05