Table 2.
Heparan sulphate and syndecan-1 concentrations and total circulating quantity at the end of the experiment
| Concentration | Quantity | |||||
|---|---|---|---|---|---|---|
| Baseline | After haemorrhage | Resuscitated | Resuscitated | |||
| HS (μg/ml) | HS (μg/kg) | |||||
| FFP | 22 ± 20 | 85 ± 37 | 53 ± 21 | *# | 2879 ± 1075 | † |
| ALB | 11 ± 6 | 88 ± 46 | 59 ± 33 | *# | 3318 ± 1814 | † |
| RA | 15 ± 10 | 79 ± 37 | 92 ± 28 | † | 3731 ± 777 | † |
| SHAM | 20 ± 13 | 37 ± 19 | 37 ± 25 | 1683 ± 1396 | ||
| Syndecan-1 (ng/ml) | Syndecan-1 (ng/kg) | |||||
| FFP | 15.3 ± 3.1 | 20.6 ± 6.1 | 19.5 ± 4.2 | 1061 ± 219 | † | |
| ALB | 15.1 ± 4.8 | 16.5 ± 4.0 | 18.0 ± 5.0 | 970 ± 240 | † | |
| RA | 16.1 ± 3.3 | 17.5 ± 4.5 | 22.6 ± 6.3 | *† | 906 ± 253 | † |
| SHAM | 16.3 ± 2.0 | 16.3 ± 3.1 | 14.5 ± 1.9 | 605 ± 145 | ||
Values are means ± SD. The change in concentration after resuscitation compared to after haemorrhage within groups was evaluated with paired t test corrected for multiple analyses with the Bonferroni correction (*P < 0.05). Differences in between groups after resuscitation was analysed with one-way repeated measurement ANOVA followed by post hoc testing using the Newman-Keuls correction
FFP fresh frozen plasma, ALB albumin, RA Ringer’s acetate
#Significant difference compared to the Ringer’s acetate group
†Significant difference compared to SHAM, P < 0.05