Fig. 2.

Sequence specificity profiles of MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14 using trypsin-generated human peptide libraries. Identified cleavage sites are summarized as heat maps showing relative amino acid occurrence. P6–P6′ subsite positions are shown on the x axes with the identified cleavage site between P1 and P1′. Plotted amino acids are indicated on the y axes with single-letter codes. Please refer to Supplementary Fig S2 for corresponding results using GluC-generated peptide libraries.