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Gadd45a inhibits hepatic fibrosis through the suppression of transforming growth factor-β/Smad signaling. A: Effects of Gadd45 on PAI-1-Luc activity in HSCs treated with pcDNA3.1, Gadd45a, and Gadd45a siRNA in both the CCl4 and saline groups; B: Effects of Gadd45 on (CAGA)9 MLP-Luc activity in HSCs treated with pcDNA3.1, Gadd45a, and Gadd45a siRNA in both the CCl4 and saline groups. HSC: Hepatic stellate cell; TGF: Transforming growth factor.
