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. 2016 Mar 4;6:22477. doi: 10.1038/srep22477

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Targeted next generation exome sequencing results for 6 genes (APEX1, PARP1, MSH2, MSH6, MLH2, PMS2) performed on the Illumina Miseq platform and analyzed with Avadis NGS software. The total number of sequence variants identified for all the genes in each specimen are graphed, and specimens are grouped by case. ‘Common’ variants (those present in all specimens from a case) are illustrated in solid black bars; ‘Shared’ variants (those present in more than one but not all specimens/case) are illustrated in solid grey bars and ‘unique’ variants (those present only in one specimen/case) are illustrated in diagonal grey stripped bars. Specimens with MGMT promoter methylation are indicated with an asterisk (*).