Figure 7. Kaplan Meier survival, myocardial ATP levels and echocardiographic properties in young or old WT and MIF−/− mice treated with or without the autophagy inducer rapamycin.
Rapamycin treatment (2 mg/kg body weight/d, i.p.) were initiated when MIF−/− mice were 22-month old for 2-month. (A) Kaplan-Meier survival curve of old WT and MIF−/− mice as well as old MIF−/− mice treated with rapamycin (Rapa); (B) Myocardial ATP levels; (C) LV Wall thickness; (D) Septal thickness; (E) LV end diastolic diameter (LVEDD); (F) LV end systolic diameter (LVESD); and (G) Fractional shortening. Mean ± SEM, n = 7–9 mice per group, *p < 0.05 vs. WT young group, #p < 0.05 vs. WT old group, †p < 0.05 vs. MIF−/− old group.