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. 2016 Mar 4;6:22592. doi: 10.1038/srep22592

Figure 2. Envelope (E) gene mutation map of DENV-1 genotype III epidemic strains/variants.

Figure 2

The analysis included 744 complete E gene sequences generated from November 2012 to end of May 2014. The figure illustrates temporal pattern of emergence, maintenance and extinction of each variant during the study period. Arrows indicate the transmission period of each variant. A timeline is given below the figure with numbers 1–12 to represent January to December in respective years. Substitutions shown are the E gene based signature mutations of each variant. Initial substitutions were named as founder (primary) substitutions and have been shown with an asterisk. Those that appeared later in respective variants were named as non-founder (secondary) substitutions (without an asterisk) in the text. Those shown in red are “fixed” non-synonymous substitutions. Remaining residues are “fixed” synonymous substitutions. Positions of all amino acid substitutions are shown at the E gene level, whereas the synonymous substitutions are numbered from the beginning of the structural polyprotein. D1GIII = DENV-1 genotype III, n = number of sequences belonging to each variant, WT = wild type isolates.