Table 5. Summary of the differentially expressed plasma metabolites in patients of Pre-AMS-S relative to Pre-AMS-R.
| Metabolites | Metabolic pathway | VIPb | %RSDc | p-valued | q-value | Ratio (Pre-AMS-S/Pre-AMS-R) |
|---|---|---|---|---|---|---|
| ESI+ | ||||||
| Sphingomyelin(d18:1/16:0) | Sphingolipid metabolism | 4.40 | 7.4 | 4.27E-04 | 5.69E-03 | 2.59 |
| Phosphatidylcholine(38:5) | Phospholipid metabolism | 3.04 | 6.8 | 2.97E-03 | 2.70E-02 | 2.36 |
| Glutamic acida | Glutamine and glutamate metabolism | 1.01 | 8.0 | 1.23E-03 | 1.26E-02 | 2.10 |
| Glyceric acida | Glycine and Serine Metabolism | 1.94 | 4.4 | 1.35E-04 | 2.13E-03 | 1.82 |
| ESI− | ||||||
| 12,13-DiHOME | Fatty acid metabolism | 1.33 | 8.3 | 2.83E-03 | 2.54E-02 | 1.73 |
aMetabolites validated by reference standards. The others were putatively annotated metabolites.
bVariable Importance in Projection.
cVariation of the metabolites concentrations in QC samples expressed as relative standard deviation (%RSD).
dP means p value obtained from Student’s t-test.