Figure 6.

(a) Arthritis index (AI) evaluation. Arthritis was almost absent in mice in which the activity of vascular endothelial growth factor (VEGF) and of high‐mobility group box 1 (HMGB1) had been blocked at the same time. *P < 0·01 versus control collagen antibody‐induced arthritis (CAIA) mice. (b) Haematoxylin and eosin sections of joints from control arthritic, sFlt1‐ and HMGB1+sFlt1‐treated arthritic mice obtained on day 21 of arthritis. Magnification ×200; n = 10 sections per joints; n = 5 mice per group.