Table 3. Ki-values for different inhibitors.
| inhibitor | Enzyme | Ki (3) [μM] | Ki (NAD+) [μM] |
|---|---|---|---|
| NAM | Sirt3 | 93.0 ± 8.5 | 45.0 ± 14.2 |
| Sirt6 | 451.0 ± 60.7 | 415.0 ± 45.1 | |
| Ex-527 | Sirt6 | 100.0 ± 11.0 | n.d. |
| Quercetin | Sirt6 | 21.0 ± 3.4 | n.d. |
| S2iL5 | Sirt2 | 0.6 ± 0.2 | n.d. |
| 8 | Sirt2 | 0.08 ± 0.02 | n.d. |
| Sirt3 | 0.1 ± 0.02 | n.d. | |
| Sirt6 | 0.4 ± 0.1 | n.d. | |
| Sirt6a | 1.1 ± 0.1e | n.d. | |
| Sirt6b | 1.9 ± 0.2e | n.d. | |
| 9 | Sirt6c | 0.6 ± 0.1e | n.d. |
| Sirt6d | 1.7 ± 0.5e | n.d. | |
| 10 | Sirt2 | 0.3 ± 0.1 | n.d. |
| 11 | Sirt2 | 50.0 ± 9.9 | n.d. |
a2.5% cis isomer.
b25% cis isomer.
c72.4% cis isomer.
d29.7% cis isomer.
eIC50 value, n.d. not determined.