Table 3.
Risk factors for patient non-adherence to directly acting antivirals for treatment of hepatitis C
| Ledipasvir/sofosbuvir | p value | Ledipasvir/sofosbuvir + GS-9451 | p value | Ledipasvir/sofosbuvir + GS-9669 | p value | |
|---|---|---|---|---|---|---|
| Sex: mean adherence ± SD (n) | ||||||
| Male | 96.7 ± 0.9 (14) | 0.93 | 96.8 ± 1.1 (14) | 0.73 | 95.2 ± 2.6 (10) | 0.87 |
| Female | 96.8 ± 1.1 (6) | 97.6 ± 0.0 (3) | 94.6 ± 2.5 (8) | |||
| Age* | R 2 = 0.02 | 0.59 | R 2 = 0.025 | 0.54 | R 2 = 0.019 | 0.59 |
| Race | ||||||
| White | 99.1 ± 0.9 (4) | 0.09 | 96.4 ± 3.6 (2) | 0.85 | 97.6 (1) | N/A** |
| Black | 96.1 ± 0.8 (16) | 97.0 ± 0.9 (15) | 94.8 ± 1.9 (17) | |||
| Highest education: mean adherence ± SD (n) | ||||||
| Masters | 100.0 (1) | 0.34*** | None | 0.36 | None | 0.88 |
| College graduate (4 year) | 100.0 (2) | 95.2 ± 0.0 (1) | 92.9 ± 4.8 (3) | |||
| College graduate (2 year) | 95.2 ± 1.5 (6) | 99.4 ± 1.2 (4) | 98.8 + 1.2 (2) | |||
| High school graduate | 96.6 ± 0.9 (9) | 96.6 ± 1.6 (7) | 94.4 ± 3.6 (8) | |||
| 11th grade or less | 97.02 ± 3.0 (2) | 95.7 ± 1.9 (5) | 95.2 ± 1.7 (4) | |||
| Currently employed | ||||||
| Yes | 97.8 ± 0.8 (9) | 0.19 | 98.4 ± 1.6 (3) | 0.73 | 98.2 ± 1.1 (4) | 0.28 |
| No | 95.9 ± 1.1 (11) | 97.6 ± 1.1 (11) | 93.3 ± 2.5 (12) | |||
| Recent substance abuse | ||||||
| Yes | 96.4 ± 1.4 (8) | 0.01 | 98.4 ± 0.8 | 0.19 | 92.5 ± 3.8 (7) | 0.28 |
| No | 99.4 ± 0.3 (12) | 95.6 ± 1.8 (6) | 96.5 ± 1.5 (11) | |||
| Diagnosed psychiatric disease | ||||||
| Yes | 95.8 ± 1.5 (7) | 0.32 | 97.3 ± 1.3 (7) | 0.75 | 92.6 ± 3.4 (8) | 0.23 |
| No | 97.3 ± 0.7 (13) | 96.7 ± 1.3 (10) | 96.9 ± 1.6 (10) | |||
| Center for Epidemiological Studies depression (CES-D) score# | ||||||
| CES-D ≥8 | 97.8 ± 0.6 (9) | 0.40 | ||||
| CES-D <8 | 96.2 ± 0.85 (43) | |||||
| Self-reported self-efficacy | ||||||
| You will be able to take all or most of the study medication as directed? | ||||||
| Not at all/somewhat/very sure | 96.0 ± 1.9 (6) | 0.53 | 95.7 ± 1.9 (5) | 0.41 | 89.3 ± 6.5 (4) | 0.08 |
| Extremely sure | 97.0 ± 0.6 (14) | 97.4 ± 1.0 (12) | 96.6 ± 1.2 (14) | |||
| The medication will have a positive impact on your health? | ||||||
| Not at all/somewhat/very sure | 96.7 ± 1.1 (11) | 0.73 | 96.6 ± 1.3 (9) | 0.47 | 94.8 ± 2.5 (11) | 0.91 |
| Extremely sure | 97.2 ± 0.9 (8) | 98.0 ± 1.3 (7) | 95.2 ± 2.3 (7) | |||
| In general, how satisfied are you with the overall support you get from your friends and family members? | ||||||
| Very or somewhat dissatisfied/somewhat satisfied | 96.8 ± 1.7 (3) | 0.95 | 97.2 ± 1.6 (6) | 0.81 | 89.3 ± 6.5 (4) | 0.08 |
| Very satisfied | 96.7 ± 0.79 (17) | 96.8 ± 1.2 (11) | 96.6 ± 1.2 (14) | |||
| To what extent do your friends or family members help you remember to take your medication? | ||||||
| Not at all/A little/somewhat | 96.6 ± 0.8 (8) | 0.47 | 98.6 ± 1.0 (5) | 0.53 | 95.2 ± 2.3 (7) | 0.82 |
| A lot | 96.2 ± 1.3 (9) | 96.3 ± 1.5 (9) | 95.9 ± 2.2 (7) | |||
| Not applicable | 98.8 ± 1.2 (3) | 96.0 ± 2.1 (3) | 92.9 ± 6.3 (4) | |||
| Do you have any children? | ||||||
| Yes | 96.3 ± 0.8 (15) | 0.27 | 97.4 ± 1.2 (10) | 0.92 | 92.9 ± 1.7 (12) | 0.61 |
| No | 98.1 ± 1.2 (5) | 97.1 ± 1.9 (5) | 91.1 ± 3.1 (4) | |||
| Do any children live with you? | ||||||
| Yes | 97.4 ± 0.7 (15) | 0.09 | 97.9 ± 1.1 (9) | 0.90 | 95.9 ± 1.9 (11) | 0.30 |
| No | 94.4 ± 2.3 (4) | 97.6 ± 1.8 (5) | 91.4 ± 4.7 (5) | |||
| Perceived stress score* | R 2 = 0.0003 | 0.94 | R 2 = 0.14 | 0.14 | R 2 = 0.029 | 0.50 |
* Pearson’s correlations
** Cannot compare with one value n = 1
*** Excluding master's degree, which only had 1 value
#CES-D Score ≥8 associated with depression. Unable to perform analysis for each arm given the small numbers of patients with CES-D score ≥8