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. Author manuscript; available in PMC: 2016 Mar 4.
Published in final edited form as: Neurotoxicology. 2014 May 2;44:140–148. doi: 10.1016/j.neuro.2014.04.007

Fig. 5.

Fig. 5

Model of the effects of the downregulation of Pink1 in CAD and M17 cells at mitochondria level. Pink1 absence produces a lower mitochondrial metabolism, leading to cell death when cells are exposed to the toxic effects of C2-ceramide. It is also proposed that the inhibition of the PI3K/Akt pathway by C2-ceramide could regulate the fusion/fission machinery, but this has to be addressed in neurons. Likewise, there is a decrease in the expression of Drp1 and Mfn2 and an increase of Fis1, related to mitochondrial fragmentation.

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