Table 1.

Eligibility criteria

Any patient undergoing endoscopic retrograde cholangiopancreatography (ERCP) in whom pancreatic stent placement is planned for post-ERCP pancreatitis prevention, is at least 18 years old, provides informed consent, and:
Has one of the following criteria:	Or two of the following criteria:
Clinical suspicion of sphincter of Oddi dysfunction	Age under 50 years old and of female gender
History of post-ERCP pancreatitis	History of recurrent pancreatitis
Pancreatic sphincterotomy	At least 3 pancreatic injections, with at least 1 injection to tail
Pre-cut (access) sphincterotomy	Pancreatic acinarization
Difficult cannulation	Pancreatic brush cytology
Short duration (≤1 min) balloon dilation of intact biliary sphincter
Exclusion criteria
Ampullectomy
Case in which a pancreatic stent is placed for therapeutic intent
Unwillingness or inability to consent for the study
Pregnancy
Breastfeeding mother
Standard contraindications to ERCP
Allergy to aspirin or NSAIDs
Known renal failure (creatinine >1.4 mg/dl)
Ongoing or recent (within 2 weeks) hospitalization for gastrointestinal hemorrhage
Ongoing or recent (within 1 week) hospitalization for acute pancreatitis
Known chronic calcific pancreatitis
Pancreatic head mass
Procedure performed on major papilla/ventral pancreatic duct in patient with pancreas divisum (no manipulation of minor papilla)
ERCP for biliary stent removal or exchange without anticipated pancreatogram
Subjects with prior biliary sphincterotomy now scheduled for repeat biliary therapy without anticipated pancreatogram
Anticipated inability to follow protocol
Absence of rectum

NSAIDs non-steroidal anti-inflammatory drugs