Table 1.

Co-localization coefficient of inflammasome proteins.

Pearson’s co-localization coefficient (PCC) of NLRP1 and NLRP3 with PYCARD, caspase-1, caspase-5 and caspase-8, in LPS-primed and Aβ₄₂₋stimulated CD14+ monocyte of patients with a diagnosis of either severe or moderate (MILD) Alzheimer’s Disease (AD) and mild cognitive impairment (MCI). Result obtained in and in age-and sex-matched healthy controls (HC) are also shown. Index reference values: PC range= −1 and +1

PCC	severe AD	MILD AD	MCI	HC
NLRP1+ PYCARD +	0.8ac (0.7-0.82)	0.8 de (0.7-0.82)	0.5ad (0.3-0.6)	0.4ce (0.3–0.5)
NLRP1+ CASPASE-1+	0.6 (0.4-0.7)	0.8 (0.7-0.84)	0.6 (0.4-0.65)	0.5 (0.5-0.7)
NLRP1+ CASPASE-5+	0.7bac (0.5–0.8)	0.4b (0.23-0.5)	0.3a (0.1-0.32)	0.3c (0.2-0.5)
NLRP3+ PYCARD +	0.8ac (0.6-0.82)	0.8 de (0.7-0.82)	0.6ad (0.5-0.7)	0.5ce (0.4-0.6)
NLRP3+ CASPASE-1+	0.9bac (0.8-0.9)	0.8bde (0.5-0.8)	0.5ad (0.4-0.56)	0.3ce (0.3-0.4)
NLRP3+ CASPASE-8+	0.8ac (0.7-0.85)	0.6 (0.5-0.72)	0.5a (0.3-0.55)	0.5c (0.3-0.6)

Median values, interquartile range and statistical significances are presented (p <0.05)

^aAD vs. MCI

^bAD vs. MILD AD

^cAD vs. HC

^dMILD AD vs. MCI

^eMILD AD vs. HC