Table 4.
Risk modification of early adulthood obesity (mid-20s to mid-40s) by hepatitis virus infection, alcohol consumption, and diabetes mellitus on HCC development: AOR* (95% CI) using multivariate logistic regression analyses
| Variables | Cases N=622 |
Controls N=660 |
Model | AOR (95% CI) | P | |
|---|---|---|---|---|---|---|
| HCV/HBV* | Early Adulthood Obesity | (1)† | ||||
| No | No | 266 | 589 | 1 (reference) | ||
| Yes | No | 281 | 24 | 31.7 (19.3–52.3) | <.0001 | |
| No | Yes | 48 | 46 | 2.5 (1.5–4.3) | <.0001 | |
| Yes | Yes | 27 | 1 | 72.5 (9.2–574.2) | <.0001 | |
| Diabetes | Early Adulthood Obesity | (2)‡ | ||||
| No | No | 375 | 548 | 1 (reference) | ||
| Yes | No | 172 | 65 | 3.9 (2.6–5.7) | <.0001 | |
| No | Yes | 39 | 33 | 3.3 (1.7–6.4) | <.0001 | |
| Yes | Yes | 36 | 14 | 6.5 (3.2–13.5) | <.0001 | |
| Alcohol | Early Adulthood Obesity | (3)§ | ||||
| No | No | 155 | 273 | 1 (reference) | ||
| Yes | No | 392 | 340 | 2.1 (1.5–3.0) | <.0001 | |
| No | Yes | 25 | 22 | 2.7 (1.2–5.9) | <.0001 | |
| Yes | Yes | 50 | 25 | 5.0 (2.4–10.1) | <.0001 |
AOR= Adjusted Odds Ratio; HBV, hepatitis B virus; HCV, hepatitis C virus
Model (1) adjustment for age, ethnicity, education level, alcohol drinking, cigarette smoking, history of diabetes, physical activity, and family history of cancer
Model (2) adjustment for age, ethnicity, HCV, HBV, education level, alcohol drinking, cigarette smoking, physical activity, and family history of cancer
Model (3) adjustment for age, ethnicity, HCV, HBV, education level, history of diabetes, cigarette smoking, physical activity, and family history of cancer