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AzEPI-bound structures of Aplysia AChBP and chick α4β2 nAChR. Relevant residues in yellow are from the (+)-face of AChBP or the α4 subunit while relevant residues in aquamarine are from the (−)-face of AChBP or the β2 subunit. The AzEPI-docked AChBP model was calculated on the basis of the corresponding crystal structure (2BYQ) (22). The α4β2 interface was constructed using 2BYQ as the scaffold.
