Table 1.
Clinicopathological characteristics of primary surgical breast cancer specimens
| Characteristic | Total patients | Luminal phenotype | HER-2+ phenotype | Basal-like phenotype |
|---|---|---|---|---|
| Total sample size, n (%) | 45 (100%) | 15 (33%) | 15 (33%) | 15 (33%) |
| Age (y) | ||||
| Median age (range) | 56 (31-88) | 59 (41-73) | 58 (31-88) | 48 (34-79) |
| <50 | 19 (42%) | 5 (33%) | 6 (40%) | 8 (53%) |
| >50 | 26 (58%) | 10 (67%) | 9 (60%) | 7 (47%) |
| Patient race | ||||
| Black | 16 (36%) | 3 (20%) | 4 (27%) | 9 (60%) |
| White | 27 (60%) | 12 (80%) | 9 (60%) | 6 (30%) |
| Other | 2 (4%) | 0 | 2 (14%) | 0 |
| Histologya: IDC or IMC | 45 (100%) | 15 (100%) | 15 (100%) | 15 (100%) |
| Histologic gradeb | ||||
| Grade 1 | 0 | 0 | 0 | 0 |
| Grade 2 | 13 (29%) | 10 (67%) | 2 (14%) | 1 (7%) |
| Grade 3 | 32 (71%) | 5 (33%) | 13 (86%) | 14 (93%) |
| Tumor size (cm) | ||||
| Median size (range) | 2.3 (0.7-12) | 2.4 (1.1-5.8) | 2.1 (0.7-6) | 2.5 (2-12) |
| <2 | 10 (22%) | 3 (20%) | 6 (40%) | 1 (7%) |
| 2-5 | 30 (67%) | 11 (73%) | 8 (53%) | 11 (73%) |
| >5 | 5 (11%) | 1 (7%) | 1 (7%) | 3 (20%) |
| Multifocal disease | 8 (18%) | 4 (27%) | 3 (20%) | 1 (7%) |
| Associated DCIS | 37 (82%) | 14 (93%) | 14 (93%) | 9 (60%) |
| Stage | ||||
| 1 | 11 (24%) | 4 (27%) | 5 (33%) | 2 (14%) |
| 2 | 27 (60%) | 8 (53%) | 8 (53%) | 11 (73%) |
| 3 | 7 (16%) | 3 (20%) | 2 (14%) | 2 (14%) |
| 4 | 0 | 0 | 0 | 0 |
Abbreviations: DCIS, ductal carcinoma in situ; HER-2, human epidermal growth factor receptor 2; IDC, infiltrating ductal carcinoma; IMC, infiltrating mammary carcinoma; TNBC, triple-negative breast cancer.
a
The IMCs were all the luminal subtype.
b
Of the grade 2 tumors, 10 were luminal, 2 were HER-2+, and 1 was TNBC.