Table 3.
Anti-proliferative activity (IC50 values) of the selected Job’s tears extracts on human colon adenocarcinoma cell line (HT-29) after a 24 h incubation.
| Solvents | Cultivars | Parts use | Code | IC50 (μg/ml) |
|---|---|---|---|---|
| Methanol | Thai Black Phayao (TBP) | Hull | M-HTBP-N1 | 203.98 ± 2.21 |
| M-HTBP-N2 | 18.75 ± 0.92 | |||
| M-HTBP-B1 | 337.66 ± 0.39 | |||
| M-HTBP-B2 | 19.24 ± 0.67 | |||
| M-HTBP-R1 | 54.39 ± 0.46 | |||
| M-HTBP-R2 | 290.76 ± 0.21 | |||
| M-HTBP-S1 | 208.94 ± 0.51 | |||
| M-HTBP-S2 | 67.55 ± 1.57 | |||
| Whole | M-WTBP-B2 | 136.71 ± 1.02 | ||
| M-WTBP-S2 | 301.51 ± 1.99 | |||
| Thai Black Loei (TBL) | Hull | M-HTBL-N1 | 53.05 ± 2.61 | |
| M-HTBL-B1 | 239.96 ± 1.21 | |||
| M-HTBL-B2 | 49.54 ± 0.31 | |||
| M-HTBL-R1 | 31.02 ± 1.18 | |||
| M-HTBL-R2 | 11.61 ± 0.95 | |||
| M-HTBL-S1 | 16.65 ± 0.75 | |||
| M-HLBL-N1 | 108.11 ± 0.71 | |||
| M-HLBL-B2 | 297.45 ± 1.72 | |||
| M-HLBL-R1 | 348.12 ± 0.22 | |||
| M-HLBL-R2 | 206.49 ± 1.23 | |||
| M-HLBL-S2 | 216.87 ± 1.23 | |||
| Laos White Loei (LWL) | Hull | M-HLWL-R1 | 120.19 ± 0.13 | |
| M-HLWL-R2 | 53.71 ± 0.85 | |||
| M-HLWL-S1 | 171.81 ± 1.87 | |||
| Whole | M-WLWL-N2 | 74.94 ± 1.63 | ||
| Laos Black Luang phra bang (LB) | Hull | M-HLB-R1 | 53.81 ± 2.34 | |
| Hexane | Thai Black Phayao (TBP) | Hull | H-HTBP-B2 | 39.95 ± 1.34 |
| H-HTBP-B4 | 36.86 ± 1.42 | |||
| H-HTBP-S4 | 184.48 ± 0.28 | |||
| Whole | H-WTBP-S4 | 112.50 ± 2.89 | ||
| Laos White Loei (LWL) | Hull | H-HLWL-S4 | 116.54 ± 1.64 | |
| Whole | H-WLWL-R2 | 13.36 ± 0.67 | ||
| Laos Black Luang phra bang (LB) | Hull | H-HLB-S4 | 56.98 ± 0.83 | |
| Whole | H-WLB-S4 | 38.83 ± 1.32 | ||
| Cisplatin | 1.94 ± 0.29 | |||
| Doxorubicin | 8.21 ± 0.72 | |||
| Vincristine | 2.11 ± 2.88 | |||
| Fluorouracil | 0.12 ± 0.05 | |||
| The commercial product | ND | |||
Note: ND = not detected.