Table 2.
Cyclophosphamide pharmacokinetic parameters. Summary statistics for empirical Bayes estimates obtained from final population pharmacokinetic model.
| Study dose | Age (years) | BW (kg) | BSA (m2) | Dose (mg) | CL (L/h/m2) | V1 (L) | AUC (mg/ml min) |
|---|---|---|---|---|---|---|---|
| 1 | 11.2 ± 4.0 | 40.8 ± 22.5 | 1.24 ± 0.38 | 314 ± 95 | 1.83 ± 1.07 | 17.3 ± 8.2 | 10.3 ± 5.3 |
| 5 | 11.3 ± 4.0 | 41.1 ± 21.9 | 1.25 ± 0.37 | 314 ± 92 | 3.68 ± 1.43 | 17.4 ± 7.9 | 4.7 ± 1.7 |
BW – body weight; BSA – body surface area; CL – clearance; V1 – volume of distribution in the central compartment; AUC – area under the plasma concentration-time curve; SD – standard deviation. All values indicate mean ± SD.