TABLE 2.
Case-control univariate analysis of risk factors and inflammatory breast cancer subtypes
| Subtypes of Inflammatory Breast Cancer | ||||||
|---|---|---|---|---|---|---|
| Triple-negative (n=64) | Her2neu + (n=85) | Luminal (n=75) | ||||
| No. cases | OR* (95% CI) | No. cases | OR* (95% CI) | No. cases | OR* (95% CI) | |
| Age, year | ||||||
| > 50 | 34 | Referent | 45 | Referent | 41 | Referent |
| ≤ 50 | 30 | 0.95 (0.56–1.61) | 40 | 0.95 (0.60–1.53) | 34 | 0.89 (0.54–1.46) |
| Age at Menarche | ||||||
| ≥ 13 | 29 | Referent | 49 | Referent | 35 | Referent |
| < 13 | 32 | 1.52 (0.89–2.61) | 36 | 1.01 (0.63–1.63) | 37 | 1.46 (0.88–2.41) |
| Parity | ||||||
| Nulliparous | 9 | Referent | 8 | Referent | 15 | Referent |
| Parous | 55 | 2.03 (0.97–4.27) | 76 | 3.17 (1.48–6.80) | 67 | 1.55 (0.82–2.95) |
| Number of Children | ||||||
| Nulliparous | 9 | Referent | 8 | Referent | 13 | Referent |
| 1 child | 11 | 2.20 (0.86–5.66) | 13 | 2.92 (1.14–7.46) | 13 | 1.82 (0.79–4.19) |
| ≥ 2 children | 44 | 1.99 (0.94–4.24) | 63 | 3.23 (1.49–6.99) | 48 | 1.49 (0.77–2.88) |
| Number of Abortions / Miscarriages | ||||||
| 0 | 45 | Referent | 53 | Referent | 56 | Referent |
| ≥ 1 | 19 | 0.91 (0.56–1.72) | 31 | 1.26 (0.77–2.01) | 18 | 0.69 (0.39–1.23) |
| Age at First Pregnancy | ||||||
| ≥ 26 | 11 | Referent | 26 | Referent | 21 | Referent |
| < 26 | 44 | 3.90 (1.93–7.88) | 49 | 1.88 (1.10–3.20) | 40 | 1.88 (1.05–3.36) |
| Breastfeeding History | ||||||
| Never | 29 | Referent | 27 | Referent | 31 | Referent |
| Ever | 23 | 0.35 (0.19–0.64) | 48 | 0.83 (0.45–1.34) | 26 | 0.36 (0.20–0.66) |
| Body Mass Index (kg/m2) | ||||||
| < 25 | 14 | Referent | 15 | Referent | 17 | Referent |
| ≥ 25 | 50 | 3.77 (2.00–7.08) | 70 | 4.95 (2.72–8.98) | 57 | 3.51 (1.96–6.29) |
| Smoking History | ||||||
| Never | 43 | Referent | 45 | Referent | 41 | Referent |
| Ever | 20 | 0.96 (0.54–1.69) | 40 | 1.84 (1.14–2.96) | 34 | 1.71 (1.03–2.82) |
| Menopausal Status | ||||||
| Premenopausal | 20 | Referent | 30 | Referent | 22 | Referent |
| Postmenopausal | 42 | 1.44 (0.74–2.81) | 54 | 1.09 (0.61–1.96) | 53 | 1.58 (0.85–2.96) |
| Breast Cancer Family History | ||||||
| No | 54 | Referent | 70 | Referent | 63 | Referent |
| Yes | 4 | 0.22 (0.08–0.61) | 8 | 0.33 (0.16–0.72) | 3 | 0.14 (0.04–0.45) |
*
Odds ratio and 95% CI were obtained from case-control comparison using multinomial logistic regression analysis adjusted for age.
Abbreviations: IBC (inflammatory breast cancer), BMI (body mass index), CI (confidence interval).