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. Author manuscript; available in PMC: 2017 Jan 5.
Published in final edited form as: ChemMedChem. 2015 Nov 26;11(1):43–56. doi: 10.1002/cmdc.201500447

Figure 5. Molecular modeling of 7b (SCA-107) binding site in E. coli SecA. 6A.

Figure 5

Docking was done in SYBYL 2.0 using PDB (2FSG) with SecA dimers A and B. 7b binds to the interface of the A and B monomers, closer to A (6A), partially blocking the entrance to the ATP site. 6B: SCA-107 surrounded by amino acid residues.