Skip to main content
. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Nat Rev Nephrol. 2015 Nov 23;12(2):110–122. doi: 10.1038/nrneph.2015.176

Figure 2. The effect of PRKCA genotype on blood pressure response to hydrochlorothiazide in participants from five independent studies (PEAR, GERA, NORDIL, GENRES and MILAN).

Figure 2

Participants were grouped according to the genotype of an intronic single nucleotide polymorphism, rs16960228, in the gene that encodes protein kinase Cα. The a | diastolic blood pressure (DBP) responses and b | systolic blood pressure (SBP) responses were greater in carriers of AA and AG alleles than in homozygous carriers of GG alleles in four of the five studies. The blood pressure responses are adjusted for pretreatment blood pressure levels, age and sex. P values are for contrast of adjusted means between genotype groups. Asterisks indicate replication cohorts. Permission obtained from the American Heart Association © Turner, S. T. et al. Hypertension 62, 391–397 (2013).