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Comparison of Adverse Outcome Pathways and Pathways of Toxicity
| AOP | PoT |
|---|---|
| Spans from exposure to population effects | Spans from molecular initiating events to cell and tissue effects |
| Narrative, low level of detail | Molecular, high level of detail |
| Biased by existing knowledge | Untargeted identification, causality |
| Not quantitative, no flux, no dynamics | Aiming for quantitative relations, fluxes |
| No validation yet | Mechanistic validation by Evidence-based Toxicology suggested |
