Table 3.
IC50 values of h12/15-LOX inhibitors selected for the structure-activity relationship study, errors are in parentheses when available. Experiments were conducted in the presence of 10 µM AA and 0.01% TritonX-100. Each experiment was performed in duplicate with at least four different inhibitor concentrations.
| Compound | Structure | %Inhibition (20 µM) |
IC50 (±SD) (µM) |
HT-22 Survival % (5 µM) |
|---|---|---|---|---|
| 99089 |  |
94% | 3.4 (0.5) | 20 |
| 20MLS0001194968 |  |
14% | >50 | |
| 21MLS0002473395 |  |
4% | >50 | |
| 22MLS000035498 |  |
29 | > 50 | |
| 23MLS000547918 |  |
32% | >50 | |
| 24MLS000547918 |  |
35% | >50 |