Table 1. Variations in mean arterial pressure and heart rate throughout the experiment in all groups.
Mean Arterial Pressure (mmHg) | ||||
Groups | t0—Baseline | t1–2 h post-LPS | t2 –post-HSA | t3–1 h post-HSA |
SHAM | 126 [95–142] | 118 [84–137] | 123 [88–136] | 134 [101–149] |
LPS | 131 [107–136] | 113 [76–138] | 121 [53–148] | - |
LPS+0.9%NaCl | 121 [95–134] | 114 [61–140] | 100 [71–131] | - |
LPS+4%HSA | 124 [110–138] | 110 [82–140] | 89 [82–129] | 77 [40–135] |
LPS+20%HSA | 118 [101–127] | 110 [83–114] | 88 [78–118] | 71 [58–85] |
Heart Rate (bpm) | ||||
Groups | t0—Baseline | t1–2 h post-LPS | t2 –post-HSA | t3–1 h post-HSA |
SHAM | 293 [236–309] | 280 [259–335] | 287 [249–320] | 276 [259–332] |
LPS | 296 [240–354] | 295 [251–299] | 286 [249–305] | - |
LPS+0.9%NaCl | 346 [316–371] | 300 [260–334] | 350 [293–396] | - |
LPS+4%HSA | 306 [285–365] | 340 [308–365] | 397 [355–407]*##aa | 365 [305–404] |
LPS+20%HSA | 281 [217–342] | 320 [284–343] | 322 [274–354] | 257 [228–315] |
Six animals per group were studied. One rat in the LPS group died after t1, leaving 5 animals in this group at t2 (post HSA). Data are expressed as the median [interquartile range]. LPS lipopolysaccharide; HSA Human Serum Albumin.
*p<0.05, versus LPS;
## p<0.01, versus LPS+0.9%NaCl;
aa p<0.01, versus t0-Baseline.