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. 2016 Mar 4;10(3):e0004467. doi: 10.1371/journal.pntd.0004467

Fig 2. Body weight and tissue bacterial loads of Orientia-infected mice.

Fig 2

Wild-type (WT) and IL-33-/- mice were lethally challenged with O. tsutsugamushi Karp strain, as in Fig 1, and monitored daily for whole body weight. Data are presented as total weight loss/mouse (A). Weight loss in WT mice began at 2–3 dpi and continued until they were moribund (9 dpi). IL-33-/- mice had significantly less weight-loss throughout the course of disease and were not moribund at the time of termination of the experiments (9 dpi). Bacterial loads in the kidneys (B), livers (C), and lungs (D) were determined by qPCR. **, p < 0.01; ***, p < 0.001; NS, no significance.