Skip to main content
. Author manuscript; available in PMC: 2016 Mar 4.
Published in final edited form as: Clin Immunol. 2008 May 29;128(2):259–268. doi: 10.1016/j.clim.2008.03.508

Figure 6.

Figure 6

Effects of ER deficiency on disease expression in MRL/lpr mice. MRL females with differing ERα genotype were compared for excretion of urine albumin at the various ages indicated (A). Total glomerular pathology scores were determined for female MRL/lpr mice of various ERα genotypes (B). ERα null females had significantly lower pathology score compared to wildtypes. p<0.01 by Mann–Whitney analysis. Female MRL kidneys were analyzed for C3 deposition (C) in wildtype and ERα deficient mice by immunofluorescence. ERα null females had significantly lower deposition compared to wildtype mice. p<0.05 by Mann–Whitney analysis.