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. Author manuscript; available in PMC: 2016 Mar 4.
Published in final edited form as: Methods. 2014 Oct 15;72:86–94. doi: 10.1016/j.ymeth.2014.10.008

Fig. 1.

Fig. 1

Transcriptional controls and enhancers features in use for computational prediction. (A) Schematic representation of the transcriptional activity. Regulatory TFs recruit chromatin-remodeling complex (coactivators) and histone acetyltransferases (HATs). After decondensation of chromatin, regulatory TFs recruit basal transcription complex and RNA Pol II to form the initial complex and begin the transcription. (B) A classification of features used in computational models for enhancer prediction. Sequence features are those mainly relevant to TF binding regions while epigenetic features are relevant to modifications of chromatin structure.