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. Author manuscript; available in PMC: 2016 Mar 4.
Published in final edited form as: Methods. 2014 Oct 15;72:86–94. doi: 10.1016/j.ymeth.2014.10.008

Fig. 4.

Fig. 4

Concepts used to link enhancers to their target genes. (A) A schematic shows the phylogenetic profiles of two genes and an enhancer. The gene and enhancer pair that share the same phylogenetic profile are shown to interact resulting in the expression of ‘Gene B’ while ‘Gene A’ does not interact with the enhancer and is inactive. (B) A schematic shows an eQTL located within an enhancer that interacts with the shown gene. The genotype ‘A’ has a negative effect on enhancer activity resulting in a reduction in gene expression. Correlating these changes over multiple genotypes allows enhancers and genes to be linked.