Table 3.
List of splenectomy and pulmonary hypertension studies
| Ref. | Patient cohort (n) | Study design | No. of patients with splenectomy |
Method of PH diagnosis |
Comment |
|---|---|---|---|---|---|
| Hoeper et al[8] | Unexplained PHTN (61) | Retrospective | 7 | RHC | 3 patients had splenectomy for hereditary spherocytosis and trauma, one patient with ITP |
| Jaïs et al[11] | CTEPH (257) | Retrospective | 22 (8.6%) | RHC | 15 patients had splenectomy after trauma, 4 with hemolytic disorder |
| Jaïs et al[11] | Idiopathic PHTN (276) | Retrospective | 7 (2.5%) | RHC | Lower prevalence of splenectomy in idiopathic PHTN compared to prior study |
| Phrommintikul et al[38] | PHTN in Thalassemia with Hb < 10 g/dL (29) | Retrospective | 29 (75.8%) | TTE | Increased prevalence of PHTN with higher nucleated red cells, platelets and transfusion requirement in splenectomised patients than those with intact spleen. |
| Elstein et al[16] | Gaucher’s disease (134), 9 patients had PH | Retrospective | 6 | TTE | All patients with PHTN had enzyme replacement therapy |
| Stewart et al[15] | Hereditary stomatocytosis after splenectomy (9) | Retrospective | 9 | 2 RHC 1 on autopsy |
3 patients developed CTEPH, one portal hypertension |
| Palkar et al[63] | PHTN after splenectomy (9) | Retrospective | 9 | RHC | 4 patients belonged to group 1, two to group 4 and one each in groups 2, 3 and 5 |
RHC: Right heart catheterization; TTE: Transthoracic echocardiography; ITP: Immune thrombocytopenic purpura; PHTN: Pulmonary hypertension.