Fig. 4.

Neuroprotective effect of exendin-4 intranasal administration blocked by intracerebroventricular infusion of GLP-1R shRNA in the ipsilateral ventricle. a Western blot analysis of GLP-1R expression. b Quantitative results of a. Results are representative of five independent experiments from five mice. c Representative neurological deficit score 24 h after ischemia and reperfusion, n = 8. d Brain slices stained with TTC 24 h after ischemia and reperfusion and the quantitative analysis of infarct volume, n = 6, i.n. intranasal, **p < 0.01