Fig. 6.

Intranasal administration of exendin-4 exerted anti-apoptotic effect against focal brain ischemia. a Western blot analysis of Caspase-3 expression in ischemic penumbra area. b Quantitative results of a. c Photographs of Nissl staining in the hippocampus CA1 region and prefrontal cortex. Scale bar = 20 μm. d, e Percentage of healthy neurons in the hippocampus CA1 region and prefrontal cortex. Six different fields were counted per division in three separated experiments. Ex-4 exendin-4, i.n. intranasal, **p < 0.01