Table I.
Examples of Glycans with Known Naturally Occurring Antibody Specificity in Humans
| Glycan | Specificity and occurrence | Ref |
|---|---|---|
| Galactose-α-1,3-galactose (Gala1-3Galb1-4GlcNAc-R, Gal-α-1,3-Gal epitope) | Common antigen present on many animal and bacteria proteins. Anti- Gal-α-1,3-Gal antibodies occur naturally in majority of humans | (35,36) |
| N-Glycolylneuraminic acid (Neu5Gc, non-human sialic acid) | Variable amounts are found in humans with a potential to form immune complexes and impact drug PK | (37) |
| β (1,2)-Xylose α (1,3)-Fucose |
IgEs with specificity to glycans was associated with plant allergens | (38) |
| Mannobioside (Man(α-1,3)Mana) Laminaribioside (Glc(β-1,3)Glc(β)) Chitobioside (GlcNAc(β-1,4)GlcNAc(β)) |
Associated with Crohn’s disease | (39,40) |
| Gal-β-1–3-GalNAc-α GalNAc-α |
Tumor-associated antigens | (41) |