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. 2016 Jan 20;18(2):432–444. doi: 10.1208/s12248-016-9870-9

Fig. 2.

Fig. 2

Representative extracted ion chromatographs (MRM) of veratramine, 7-hydroxyl-veratramine and veratramine-3-O-sulfate in a plasma (2 ng/mL of veratramine, 4 ng/mL of 7-hydroxyl-veratramine, and 50 ng/mL of veratramine-3-O-sulfate) and b urine (70 ng/mL of veratramine, 100 ng/mL of 7-hydroxyl-veratramine, and 20 ng/mL of veratramine-3-O-sulfate) after oral administration of 20 mg/kg veratramine; and in incubations of c fRLCs with veratramine in the presence of PAPS (950 ng/mL of veratramine-3-O-sulfate) and d mRLMs with veratramine in the presence of NADPH (20 ng/mL of 7-hydroxyl-veratramine)