Table II.

Pharmacokinetic Parameters of 7-Hydroxyl-Veratramine and Veratramine-3-O-Sulfate After Oral (20 mg/kg) Administration to Male and Female Rats

PK parameters	7-Hydroxyl-veratramine		Veratramine-3-O-sulfate
	Male (n = 5)	Female (n = 5)	Male (n = 5)	Female (n = 5)
C max (ng/mL)	38.8 ± 8.6	4.21 ± 0.52**	98.8 ± 33.2	148 ± 40
AUC0–t (min μg/mL)	39.5 ± 10.9	1.83 ± 0.50**	42.7 ± 11.7	106 ± 39*
AUC0-∞ (min μg/mL)	40.1 ± 11.3	4.06 ± 2.04**	68.0 ± 35.2	129 ± 28*
t 1/2 (min)	411 ± 159	657 ± 466	524 ± 453	453 ± 111
MRT (min)	865 ± 234	1014 ± 673	861 ± 603	869 ± 141

*p < 0.05, significant difference; **p < 0.01, highly significant difference (vs. the same metabolite for male rats).