. 2015 Dec 31;18(2):395–403. doi: 10.1208/s12248-015-9857-y

Table I.

Summary of the Effect of Immunogenicity on Pharmacokinetics and Efficacy for 31 Products; Data Grouped by the Effect on Pharmacokinetics (↑ = increase, ↔ = no change, ↓ = decrease)

ADA type	CL	Number of products	Percent of total number of drugs	Efficacy	Number of products
Clearing	↑	13	42.0	↓	8
Clearing	↑	13	42.0	NR^a	5
No effect	↔	10	32.2	↔	6
No effect	↔	10	32.2	NR	4
Sustaining	↓	6	19.4	↓	1
				↔	1
				NR	4
Inconclusive	Unknown	2	6.4	NR	2
Total number of drugs		31	100		31

^a NR not reported, including about equal number of products with no mention in the labeling or labeling mentioned a conclusion could not be drawn based on limited available data