Table II.
Models Tested in the Joint Analysis of Iron and Hepcidin
| Number | Description | BIC (IS) |
|---|---|---|
| 1 | Separate models for iron and hepcidin | 5751.3 |
| 2 | Model with ksynI linear function of hepcidin concentration | 5751.0 |
| 3 | Model with ksynH linear function of iron concentration | 5749.4 |
| 4 | Model with both variables acting on each other | 5768.4 |
| 5 | ksynH linear function of iron concentration, same kloss | 5736.5 |
| 6 | ksynH linear function of iron concentration, same drel | 5728.9 |
| 7 | ksynH linear function of iron concentration, same drel, no IIV | 5728.7 |
| 8 | Mixture model on krelI | 5735.2 |
| 9 | Mixture model on krelH | 5735.3 |
| 10 | ksynH linear function of iron concentration, no rebound for hepcidin | 5731.8 |
| 11 | Final model, proportional error model | 5712.0 |
| 12 | Final model, aIron fixed to 0.001 | 5720.0 |
The log-likelihood (LL) was computed by importance sampling for all models tested. A combined error model was used except when indicated otherwise
BIC Bayesian information criterion, IS importance sampling