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. 2016 Feb 2;18(2):490–504. doi: 10.1208/s12248-016-9875-4

Table III.

Estimates of the Parameters and Their Variability for Both Models With and Without Covariates

Model without covariate Model with covariates
Parameter Estimate (RSE) Variability (RSE) Estimate (RSE) Variability (RSE)
ksynI (μmol.d. L−1) 5.48 (10) 13 (64) 7.57 (8) 15 (15)
koutI (d−1) 0.33 (10) 14 (51) 0.42 (8) 0 (-)
kloss (d−1) 0.08 (27) 129 (20) 0.14 (19) 95 (19)
krelI (μmol.d.L−1) 2.23 (14) 70 (19) 2.55 (13) 55 (22)
drel (d) 5.44 (10) 0 (−) 5.74 (5) 0 (−)
ksynH (nmol.d.L−1) 1.86 (9) 50 (12) 2.48 (5) 24 (19)
koutH (d−1) 0.58 (9) 51 (12) 0.82 (7) 57 (9)
krelH (nmol.d.L−1) 0.21 (25) 156 (13) 0.28 (21) 103 (17)
α (−) 0.03 (35) 64 (67) 0.03 (31) 87 (38)
b Iron (−) 0.29 (4) 0.29 (4)
a Hep (nmol.L−1) 0.14 (48) 0.17 (50)
b Hep (−) 0.48 (7) 0.47 (8)
−2LL (IS) 5631.0 5558.5
BIC (IS) 5721.0 5680.0

The variability is in %

RSE relative standard error, in %, d day, BIC Bayesian Information Criterion, IS importance sampling, −2LL objective function