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RSABE for Narrow Therapeutic Index drugs. The draft FDA guideline for warfarin (8) recommends that for NTI drugs, the regulatory constant (θ) should be set to log(1.111)/0.10. Four-period, two-sequence studies were simulated with 24 subjects with different s WT/s WR ratios. Simulation conditions from left to right: s WT = 0.05, s WR = 0.1; s WT = 0.1, s WR = 0.1; s WT = 0.1, s WR = 0.05
